00000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 00000002 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 00000003 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 00000004 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 00000005 - Statement - Consolidated Statement of Changes in Shareholders' Equity link:presentationLink link:calculationLink link:definitionLink 00000006 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 999014 - Disclosure - Nature of business and history link:presentationLink link:calculationLink link:definitionLink 999015 - Disclosure - Summary of significant accounting policies link:presentationLink link:calculationLink link:definitionLink 999016 - Disclosure - Research and development link:presentationLink link:calculationLink link:definitionLink 999017 - Disclosure - General and administrative link:presentationLink link:calculationLink link:definitionLink 999018 - Disclosure - Income taxes link:presentationLink link:calculationLink link:definitionLink 999019 - Disclosure - Prepaid expenses and other current assets link:presentationLink link:calculationLink link:definitionLink 999020 - Disclosure - Fixed assets, net link:presentationLink link:calculationLink link:definitionLink 999021 - Disclosure - Non-current assets right of use (ROU) link:presentationLink link:calculationLink link:definitionLink 999022 - Disclosure - Other non-current assets link:presentationLink link:calculationLink link:definitionLink 999023 - Disclosure - Retirement benefit obligation link:presentationLink link:calculationLink link:definitionLink 999024 - Disclosure - Shareholders’ equity link:presentationLink link:calculationLink link:definitionLink 999025 - Disclosure - Share-based compensation link:presentationLink link:calculationLink link:definitionLink 999026 - Disclosure - Accumulated other comprehensive income link:presentationLink link:calculationLink link:definitionLink 999027 - Disclosure - Related parties link:presentationLink link:calculationLink link:definitionLink 999028 - Disclosure - Commitments and contingencies link:presentationLink link:calculationLink link:definitionLink 999029 - Disclosure - Subsequent events link:presentationLink link:calculationLink link:definitionLink 999030 - Disclosure - Summary of significant accounting policies (Policies) link:presentationLink link:calculationLink link:definitionLink 999031 - Disclosure - Summary of significant accounting policies (Tables) link:presentationLink link:calculationLink link:definitionLink 999032 - Disclosure - Income taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 999033 - Disclosure - Prepaid expenses and other current assets (Tables) link:presentationLink link:calculationLink link:definitionLink 999034 - Disclosure - Fixed assets, net (Tables) link:presentationLink link:calculationLink link:definitionLink 999035 - Disclosure - Other non-current assets (Tables) link:presentationLink link:calculationLink link:definitionLink 999036 - Disclosure - Share-based compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 999037 - Disclosure - Accumulated other comprehensive income (Tables) link:presentationLink link:calculationLink link:definitionLink 999038 - Disclosure - Related parties (Tables) link:presentationLink link:calculationLink link:definitionLink 999039 - Disclosure - Commitments and contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 999040 - Disclosure - Nature of business and history (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999041 - Disclosure - Schedule of cash and cash equivalents (Details) link:presentationLink link:calculationLink link:definitionLink 999042 - Disclosure - Schedule of Marketable securities (Details) link:presentationLink link:calculationLink link:definitionLink 999043 - Disclosure - Schedule of fair values due to short-term nature of assets and liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 999044 - Disclosure - Summary of significant accounting policies (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999045 - Disclosure - Schedule of effective income tax rate reconciliation (Details) link:presentationLink link:calculationLink link:definitionLink 999046 - Disclosure - Schedule of deferred tax assets (Details) link:presentationLink link:calculationLink link:definitionLink 999047 - Disclosure - Schedule of tax loss carryforwards expire (Details) link:presentationLink link:calculationLink link:definitionLink 999048 - Disclosure - Income taxes (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999049 - Disclosure - Schedule of prepaid expenses and other current assets (Details) link:presentationLink link:calculationLink link:definitionLink 999050 - Disclosure - Prepaid expenses and other current assets (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999051 - Disclosure - Schedule of fixed assets,net (Details) link:presentationLink link:calculationLink link:definitionLink 999052 - Disclosure - Non-current assets right of use (ROU) (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999053 - Disclosure - Schedule of other non-current assets (Details) link:presentationLink link:calculationLink link:definitionLink 999054 - Disclosure - Other non-current assets (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999055 - Disclosure - Retirement benefit obligation (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999056 - Disclosure - Shareholders’ equity (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999057 - Disclosure - Schedule of Outstanding Stock Options (Details) link:presentationLink link:calculationLink link:definitionLink 999058 - Disclosure - Schedule of share based compensation expenses (Details) link:presentationLink link:calculationLink link:definitionLink 999059 - Disclosure - Share-based compensation (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999060 - Disclosure - Schedule of Accumulated Other Comprehensive Income (Details) link:presentationLink link:calculationLink link:definitionLink 999061 - Disclosure - Accumulated other comprehensive income (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999062 - Disclosure - Schedule of third party and related party expenses (Details) link:presentationLink link:calculationLink link:definitionLink 999063 - Disclosure - Schedule of third party and general and administrative expenses (Details) link:presentationLink link:calculationLink link:definitionLink 999064 - Disclosure - Schedule of accounts payable to related parties (Details) link:presentationLink link:calculationLink link:definitionLink 999065 - Disclosure - Schedule of accrued expenses to related parties (Details) link:presentationLink link:calculationLink link:definitionLink 999066 - Disclosure - Related parties (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999067 - Disclosure - Schedule of company obligations by contractual maturity (Details) link:presentationLink link:calculationLink link:definitionLink 999068 - Disclosure - Commitments and contingencies (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999069 - Disclosure - Subsequent events (Details Narrative) link:presentationLink link:calculationLink link:definitionLink