Related and Nonrelated Parties [Axis]
Nonrelated Party [Member]
Related Party [Member]
Equity Components [Axis]
Common Stock [Member]
Retained Earnings [Member]
AOCI Attributable to Parent [Member]
Sale of Stock [Axis]
IPO [Member]
Over-Allotment Option [Member]
American Depository Shares [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Prior Sales Agreement [Member]
Current Sales Agreement [Member]
Statistical Measurement [Axis]
Maximum [Member]
Award Type [Axis]
Share-Based Payment Arrangement, Option [Member]
Underswriters Common Share Warrants [Member]
Antidilutive Securities [Axis]
Minimum [Member]
Underswriters Warrants [Member]
ATM Offering Costs [Member]
Fair Value Hierarchy and NAV [Axis]
Fair Value, Inputs, Level 1 [Member]
Fair Value, Inputs, Level 2 [Member]
Fair Value, Inputs, Level 3 [Member]
Related Party Transaction [Axis]
Research and Development Expense Related Party [Member]
Investment Type [Axis]
Allowance For Corporate Equity [Member]
Financial Claims For Accrued Interest On Ongoing Investments [Member]
Revision of Prior Period [Axis]
Revision of Prior Period, Reclassification, Adjustment [Member]
Title and Position [Axis]
Director [Member]
Long-Lived Tangible Asset [Axis]
Software and Software Development Costs [Member]
Statement of Financial Position Location, Balance [Axis]
Other Current Assets [Member]
Statement of Income Location, Balance [Axis]
Research and Development Expense [Member]
General and Administrative Expense [Member]
AOCI, Accumulated Gain (Loss), Debt Securities, Available-for-Sale, Parent [Member]
Accumulated Foreign Currency Adjustment Attributable to Parent [Member]
Third Parties [Member]
Product and Service [Axis]
Consultants and Other Third Parties [Member]
Related Parties [Member]
Materials And Supplies [Member]
Compensation [Member]
Travel And Entertainment [Member]
Other [Member]
Accounting Legal and Other Professional [Member]
Communication and IT Related [Member]
Facility and Insurance Related [Member]
San Raffaele Hospital [Member]
Pierluigi Paracchi [Member]
Richard Slansky [Member]
Carlo Russo [Member]
Naldini [Member]
Dr.Gentner [[Member]
Consulting Agreement [Member]
Dr. Carlo Russo [Member]
Dr. Russo [Member]
Scenario [Axis]
First Indication [Member]
Second Indication [Member]
Third Indication [Member]
Amended and Restated OSR License Agreement [Member]
Sublicense Agreement [Member]
Amendment to OSR Amendedand Restated License Agreement [Member]
First Solid Cancer Indication Option Fee [Member]
Second Solid Cancer Indication Option Fee [Member]
OSR Sponsor Research Agreement [Member]
OSR [Member]
OSR Operating Leases And Office Rent [Member]
OSR Amended And Restated Licenset Agreement [Member]
AGC Manufacturing [Member]
Insurance Policy [Member]
Original OSR License Agreement [Member]
Legal Entity [Axis]
AGC Biologics Agreement [Member]
AGC Agreement [Member]
Process Transfer Agreement [Member]
Master Service Agreement [Member]
Process Transfer Agreement Agreement [Member]
Lease Agreement [Member]
AGC Biologics SPA [Member]
Subsequent Event Type [Axis]
Subsequent Event [Member]
Officers And Employees [Member]
Cover [Abstract]
Document Type
Amendment Flag
Amendment Description
Document Registration Statement
Document Annual Report
Document Quarterly Report
Document Transition Report
Document Shell Company Report
Document Shell Company Event Date
Document Period Start Date
Document Period End Date
Document Fiscal Period Focus
Document Fiscal Year Focus
Current Fiscal Year End Date
Entity File Number
Entity Registrant Name
Entity Central Index Key
Entity Primary SIC Number
Entity Tax Identification Number
Entity Incorporation, State or Country Code
Entity Address, Address Line One
Entity Address, Address Line Two
Entity Address, Address Line Three
Entity Address, City or Town
Entity Address, State or Province
Entity Address, Country
Entity Address, Postal Zip Code
Country Region
City Area Code
Local Phone Number
Extension
Written Communications
Soliciting Material
Pre-commencement Tender Offer
Pre-commencement Issuer Tender Offer
Title of 12(b) Security
No Trading Symbol Flag
Trading Symbol
Security Exchange Name
Title of 12(g) Security
Security Reporting Obligation
Annual Information Form
Audited Annual Financial Statements
Entity Well-known Seasoned Issuer
Entity Voluntary Filers
Entity Current Reporting Status
Entity Interactive Data Current
Entity Filer Category
Entity Small Business
Entity Emerging Growth Company
Elected Not To Use the Extended Transition Period
Document Accounting Standard
Other Reporting Standard Item Number
Entity Shell Company
Entity Public Float
Entity Bankruptcy Proceedings, Reporting Current
Entity Common Stock, Shares Outstanding
Documents Incorporated by Reference [Text Block]
Income Statement [Abstract]
Operating expenses
Research and development
General and administrative
Total operating expenses
Loss from operations
Other income (expense)
Other income
Finance income
Net exchange rate gain (loss)
Total other income, net
Loss before income taxes
Income tax benefit (expense)
Net loss
Net loss per share - basic
Weighted average number of shares outstanding - basic
Weighted average number of shares outstanding - diluted
Other comprehensive income (loss)
Total change of marketable debt securities
Change in foreign currency translation
Total other comprehensive income
Comprehensive loss
Defined Benefit Plan [Table]
Defined Benefit Plan Disclosure [Line Items]
Assets
Current assets
Cash and cash equivalents
Marketable securities
Prepaid expenses and other current assets
Total current assets
Non-current assets
Fixed assets, net
Other non-current assets
Total non-current assets
Total assets
Liabilities and shareholders’ equity
Current liabilities
Accounts payable
Accrued expenses
Other current liabilities
Total current liabilities
Non-current liabilities
Other non current liabilities
Retirement benefit obligation
Total long-term liabilities
Commitments and contingencies
Shareholders’ equity
Ordinary shares, no par value, 59,700,000 shares authorized and 18,289,866 and 18,216,958 shares issued and outstanding, respectively
Accumulated deficit
Accumulated other comprehensive income
Total shareholders’ equity
Total liabilities and shareholders’ equity
Statement of Financial Position [Abstract]
Common Stock, Par or Stated Value Per Share
Common Stock, Shares Authorized
Common Stock, Shares, Outstanding
Statement [Table]
Statement [Line Items]
Balance
Balance, shares
Share-based compensation
Cumulative translation adjustment
Net loss
Capital increase ATM program
Capital increase ATM program, shares
Other comprehensive income
Balance
Balance, shares
Statement of Cash Flows [Abstract]
Cash flows from operating activities
Adjustments to reconcile net loss to net cash used in operating activities:
Foreign exchange adjustment
Depreciation expense
Retirement benefit obligation
Share-based compensation
Net gain (loss) on purchase of marketable securities
Changes in operating assets and liabilities
Prepaid expenses and other current assets
Other non-current assets
Accounts payable
Accounts payable - related party
Accrued expenses
Accrued expenses - related party
Other current liabilities
Other non-current liabilities
Net cash used in operating activities
Cash flows from investing activities
Purchases of marketable securities
Proceeds from maturities of marketable securities
Purchases of fixed assets
Net cash (used in) provided by investing activities
Cash flows from financing activities
Proceeds from ATM program
Net cash provided by financing activities
Effect of exchange rate changes
Net increase (decrease) in cash and cash equivalents
Cash and cash equivalents at beginning of period
Cash and cash equivalents at end of period
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Nature of business and history
Accounting Policies [Abstract]
Summary of significant accounting policies
Research and Development [Abstract]
Research and development
General And Administrative
General and administrative
Income Tax Disclosure [Abstract]
Income taxes
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]
Prepaid expenses and other current assets
Property, Plant and Equipment [Abstract]
Fixed assets, net
Other non-current assets
Retirement Benefits [Abstract]
Retirement benefit obligation
Equity [Abstract]
Shareholders’ equity
Share-Based Payment Arrangement [Abstract]
Share-based compensation
Accumulated Other Comprehensive Income
Related Party Transactions [Abstract]
Related parties
Commitments and Contingencies Disclosure [Abstract]
Commitments and contingencies
Subsequent Events [Abstract]
Subsequent events
Basis of presentation
Principles of consolidation
Use of estimates
Cash and cash equivalents
Marketable securities
Net loss and comprehensive loss
Net loss per share
Foreign currency translation
Emerging growth company status
Fair value measurements
Segment information
Tax credit on investments in R&D
Share-based compensation
Representative warrants
Non-current assets right-of-use (“ROU”)
Fixed Assets
Impairment of long-lived assets
Deferred offering costs
Recently issued accounting pronouncements
Schedule of cash and cash equivalents
Schedule of fair values due to short-term nature of assets and liabilities
Schedule of prepaid expenses and other current assets
Schedule of fixed assets,net
Schedule of other non-current assets
Schedule of Outstanding Stock Options
Schedule of share based compensation expenses
Schedule of Accumulated Other Comprehensive Income
Schedule of third party and general and administrative expenses
Schedule of accounts payable to related parties
Schedule of accrued expenses to related parties
Schedule of company obligations by contractual maturity
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Conversion of stock, shares issued
Stock Issued During Period, Shares, New Issues
Common Stock, Shares Subscribed but Unissued
[custom:AmericanDepositoryShares]
Common stock, shares outstanding
[custom:NetListingCosts-0]
Gross sale proceeds
Shares issued
Shares issued value
Aggregate offering price
Net Income (Loss) Attributable to Parent
Retained Earnings (Accumulated Deficit)
Cash
Marketable securities
Unrealized net loss from exchange rate
Cash in bank
Cash in short-term marketable securities
Cash in hand & prepaid cards
Total cash and cash equivalents
Platform Operator, Crypto Asset [Table]
Platform Operator, Crypto Asset [Line Items]
Cash and cash equivalents
Marketable Securities
Total cash and cash equivalents and marketable securities
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Line Items]
Net loss
Comprehensive loss
Shares, Issued
Common Stock, Capital Shares Reserved for Future Issuance
Number of options shares outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Expirations in Period
Underwriters ordinary shares, warrants
Net exchange gain
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Number of shares authorized
Number of shares outstanding, percentage
Share-based payment award, options, number of shares, period increase
Number of shares available for issuance
Number of shares outstanding
Number of warrants issued to the underwriters
Exercisable percentage of warrant
Exercise price
Annual lease payment
Annual lease payment
Lease, description
Operating lease discount rate
Operating lease liability
Net present value of right of use asset and liability
Lease liability current
Long-term liability
Number of stock issued, value
Percentage of taxable income can off-set
Value added tax (VAT)
Research and development tax credit
Advances payments to suppliers
Other current assets
Other prepaids
Total
Percentage of value added tax
Value added tax refund received
Value added tax refund received short-term
Value added tax refund received long-term
Research and development tax credit
Amount utilized to offset social contributions and taxes payable
Research and development expense
Other Assets, Current
Other Prepaid Expense, Current
Software (ERP Implementation)
Computers
Furniture and fixtures
Total fixed assets
Less: accumulated depreciation
Fixed assets, net
Net of accumulated depreciation
Value added tax (VAT)
Research and development tax credit
Other non-current assets
Total
VAT credit outstanding
Right of use of asset
Other non current assets
Description of annual contributions
Percentage of total pay
Obligation amount
Accumulated Other Comprehensive Income (Loss) [Table]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Fair value of options granted
Common stock, shares issued
Ordinary shares reserved
Number of options outstanding, Beginning
Weighted average exercise price outstanding, Beginning
Weighted average remaining contractual term outstanding
Aggregate intrinsic value outstanding, Beginning
Number of options, Granted
Weighted average exercise price, Granted
Weighted average remaining contractual term, Granted
Aggregate intrinsic value , Granted
Number of options, Vested and exercised
Weighted average exercise price, Vested and exercised
Aggregate intrinsic value, Vested and exercised
Number of options, Cancelled or forfeited
Weighted average exercise price, Cancelled or forfeited
Aggregate intrinsic value, Cancelled or forfeited
Number of options outstanding, Ending
Weighted average exercise price outstanding, Ending
Aggregate intrinsic value outstanding,Ending
Number of options,Exercisable
Weighted average exercise price, Exercisable
Weighted average remaining contractual term, Exercisable
Aggregate intrinsic value, Exercisable
Number of options outstanding, Expected to vest
Weighted average exercise price outstanding, Expected to vest
Weighted average remaining contractual term (years) Outstanding expected to vest
Aggregate intrinsic value outstanding, Expected to vest
Number of options, Cancelled or forfeited
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total
Unrecognized expense
Number of options granted
Number of options available for grant
Number of stock options awarded
Exercise price per share
Number of shares expired
Weighted average fair value
Weighted average fair value of options granted
Weighted average shares
Common stock par value
Beginning Balance
Adjustment for net gain on marketable securities
Change in fair value of marketable securities
Cumulative translation adjustment
Total
Realized gain on investing activities
Unrealized gain on marketable securities
Related Party Transaction [Table]
Related Party Transaction [Line Items]
Total
Total
San Raffaele Hospital
Total
Salary and Wage, Excluding Cost of Good and Service Sold
Percentage of annual bonus
Accrued bonus
Gross bonus
Employee benefits and share based compensation
Annual fee
Gross salary
Interest expense
Gross annual compensation
Future option fees
Upfront fee
License fees
Commitments, description
Cumulative expense
Option fee
Agreement fee
Total project amounting
Payment for research agreement
Total
Less than a year
1 to 3 years
4 to 5 years
More than 5 years
Loss Contingencies [Table]
Loss Contingencies [Line Items]
Investment Owned, Balance, Principal Amount
Incurred expenses
Manufacturing cost
Percentage of royalties
Potential milestone
Royalty fees percentage
Technology transfer fee
Raw materials
Raw materials handling
Raw material costs
Raw material and third party costs
Production cost
Annual rent amount
Minimum payments amount outstanding
Finance lease agreement amount
Insurance expenses outstanding for payments related to automobile
Subsequent Event [Table]
Subsequent Event [Line Items]
cancellation fees
Non qualified stock options
Non qualified stock options term vest term
Stock option exercise price
Finance income expenses.
Change of marketable debt securities.
Capital Increase Atm Program.
Capital increase Atm program share.
Increase decrease in accounts payable related party.
Increase decrease in accrued liabilities related party.
Proceeds From Atm
American depository shares.
Net listing costs.
Net Loss and Comprehensive Loss [Policy Text Block]
General And Administrative Disclosure [Text Block]
Percentage of taxable income can off-set
Research and development tax credit
Percentage of value added tax
Value added tax refund received
Value added tax refund received short-term
Value added tax refund received long-term
Underswriters Common Share Warrants [Member]
Allowance For Corporate Equity [Member]
Emerging Growth Company Status [Policy Text Block]
Research and Development Expense Related Party [Member]
Tax Credit on Investments in Research and Development [Policy Text Block]
Representative Warrants [Policy Text Block]
Underswriters Warrants [Member]
Class of warrant or right exercisable percentage of warrants or rights
Noncurrent Assets Right of Use ROU [Policy Text Block]
Operating Lease Expense Monthly Payment.
Net present value of right of use asset and liability.
ATM Offering Costs [Member]
Cash in short-term marketable securities.
Sales Agreement [Member]
Equity Incentive Plan 2021 - 2025 [Member]
Financial Claims For Accrued Interest On Ongoing Investments [Member]
Net gain (loss) on purchase of marketable securities.
Research and development tax credit non current.
Other Noncurrent Assets.
Third Parties [Member]
Consultants and Other Third Parties [Member]
Related Parties [Member]
Materials And Supplies [Member]
Compensation [Member]
Travel And Entertainment [Member]
Other [Member]
Defined contribution plan maximum annual contributions per employee description.
Accounting Legal and Other Professional [Member]
Communication and IT Related [Member]
Facility and Insurance Related [Member]
Sharebased compensation arrangement by sharebased payment award options outstanding weighted average remaining contractual term granted.
Share based compensation arrangement by share based payment award options granted aggregate intrinsic value.
Schedule Of Accounts Payable To Related Parties [Table Text Block]
Share based compensation arrangement by share based payment award options cancelled or forfeited aggregate intrinsic value.
San Raffaele Hospital [Member]
Schedule Of Accrued Expense To Related Parties [Table Text Block]
Pierluigi Paracchi [Member]
Percentage of annual bonus
Annual fee.
Naldini [Member]
Gentner [Member]
Dr.Gentner [[Member]
Share based compensation arrangement by share based payment award equity instruments options vested in period total fair value.
Consulting Agreement [Member]
XDG Biomed LLC [Member]
Mr.Russo [Member]
Richard Slansky [Member].
Future option fees
First Indication [Member]
Second Indication [Member]
Third Indication [Member]
Upfront fee.
Amended and Restated OSR License Agreement [Member]
Sublicense Agreement [Member]
Amendment to OSR Amendedand Restated License Agreement [Member]
First Solid Cancer Indication Option Fee [Member]
Option fee.
Second Solid Cancer Indication Option Fee [Member]
Agreement fee.
Total project cash consideration.
OSR Sponsor Research Agreement [Member]
OSR [Member]
Payments by period, less than a year
OSR Operating Leases And Office Rent [Member]
Contractual obligation due in one to third year
AGC Manufacturing [Member]
Insurance Policy [Member]
Original OSR License Agreement [Member]
Percentage of Royalties.
Potential milestone.
AGC Biologics Agreement [Member]
Royalty fee percentage.
Technology transfer fee.
AGC Agreement [Member]
Process Transfer Agreement [Member]
SOW [Member]
American Depository Shares [Member]
Master Service Agreement [Member]
Process Transfer Agreement Agreement [Member]
Lease Agreement [Member]
AGC Biologics SPA [Member]
Cancellation fees.
Officers And Employees [Member]
OSR Amended And Restated Licenset Agreement [Member]
Carlo Russo [Member]
Prior Sales Agreement [Member]
Operating Expenses
Operating Income (Loss)
Nonoperating Income (Expense)
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Assets, Current
Assets, Noncurrent
Assets [Default Label]
Liabilities, Current
Liabilities, Noncurrent
Equity, Attributable to Parent
Liabilities and Equity
Gain (Loss), Foreign Currency Transaction, before Tax
Pension and Other Postretirement Benefits Expense (Reversal of Expense), Noncash
Share-Based Payment Arrangement, Noncash Expense
NetGainLossOnPurchaseOfMarketableSecurities
Increase (Decrease) in Prepaid Expense and Other Assets
Increase (Decrease) in Other Noncurrent Assets
Increase (Decrease) in Accounts Payable
Increase (Decrease) in Accrued Liabilities
Increase (Decrease) in Other Current Liabilities
Net Cash Provided by (Used in) Operating Activities
Payments to Acquire Marketable Securities
Payments to Acquire Property, Plant, and Equipment
Net Cash Provided by (Used in) Investing Activities
Net Cash Provided by (Used in) Financing Activities
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect, Disposal Group, Including Discontinued Operations
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Research, Development, and Computer Software Disclosure [Text Block]
General And Administrative Disclosure [Text Block]
Other Current Assets [Text Block]
Property, Plant and Equipment Disclosure [Text Block]
Other Assets Disclosure [Text Block]
Retirement Benefits [Text Block]
Equity [Text Block]
Share-Based Payment Arrangement [Text Block]
Commitments and Contingencies Disclosure [Text Block]
Cash and Cash Equivalents, Policy [Policy Text Block]
Marketable Securities, Policy [Policy Text Block]
Share-Based Payment Arrangement, Forfeiture [Policy Text Block]
Marketable Securities [Default Label]
Cash and Cash Equivalents, Fair Value Disclosure
Operating Lease Expense Monthly Payment
Prepaid Expense, Current
Property, Plant and Equipment, Gross
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Value Added Tax Receivable, Noncurrent
ResearchAndDevelopmentTaxCreditNoncurrent
Other Noncurrent Assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Accrued Liabilities
Contractual Obligation