00000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 00000002 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 00000003 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 00000004 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 00000005 - Statement - Consolidated Statement of Changes in Quotaholders' and Shareholders' Equity link:presentationLink link:calculationLink link:definitionLink 00000006 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 00000007 - Disclosure - Nature of business and history link:presentationLink link:calculationLink link:definitionLink 00000008 - Disclosure - Summary of significant accounting policies link:presentationLink link:calculationLink link:definitionLink 00000009 - Disclosure - Research and development link:presentationLink link:calculationLink link:definitionLink 00000010 - Disclosure - General and administrative link:presentationLink link:calculationLink link:definitionLink 00000011 - Disclosure - Income taxes link:presentationLink link:calculationLink link:definitionLink 00000012 - Disclosure - Prepaid expenses and other current assets link:presentationLink link:calculationLink link:definitionLink 00000013 - Disclosure - Fixed assets, net link:presentationLink link:calculationLink link:definitionLink 00000014 - Disclosure - Non-current assets right of use (ROU) link:presentationLink link:calculationLink link:definitionLink 00000015 - Disclosure - Other non-current assets link:presentationLink link:calculationLink link:definitionLink 00000016 - Disclosure - Retirement benefit obligation link:presentationLink link:calculationLink link:definitionLink 00000017 - Disclosure - Quotaholders’ and shareholders’ equity link:presentationLink link:calculationLink link:definitionLink 00000018 - Disclosure - Share-based compensation link:presentationLink link:calculationLink link:definitionLink 00000019 - Disclosure - Related parties link:presentationLink link:calculationLink link:definitionLink 00000020 - Disclosure - Commitments and contingencies link:presentationLink link:calculationLink link:definitionLink 00000021 - Disclosure - Subsequent events link:presentationLink link:calculationLink link:definitionLink 00000022 - Disclosure - Summary of significant accounting policies (Policies) link:presentationLink link:calculationLink link:definitionLink 00000023 - Disclosure - Summary of significant accounting policies (Tables) link:presentationLink link:calculationLink link:definitionLink 00000024 - Disclosure - Income taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 00000025 - Disclosure - Prepaid expenses and other current assets (Tables) link:presentationLink link:calculationLink link:definitionLink 00000026 - Disclosure - Fixed assets, net (Tables) link:presentationLink link:calculationLink link:definitionLink 00000027 - 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Disclosure - Summary of significant accounting policies (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 00000036 - Disclosure - Schedule of effective income tax rate reconciliation (Details) link:presentationLink link:calculationLink link:definitionLink 00000037 - Disclosure - Schedule of deferred tax assets (Details) link:presentationLink link:calculationLink link:definitionLink 00000038 - Disclosure - Schedule of tax loss carryforwards expire (Details) link:presentationLink link:calculationLink link:definitionLink 00000039 - Disclosure - Income taxes (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 00000040 - Disclosure - Schedule of prepaid expenses and other current assets (Details) link:presentationLink link:calculationLink link:definitionLink 00000041 - Disclosure - Prepaid expenses and other current assets (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 00000042 - Disclosure - Schedule of fixed assets,net (Details) link:presentationLink link:calculationLink link:definitionLink 00000043 - Disclosure - Fixed assets, net (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 00000044 - Disclosure - Non-current assets right of use (ROU) (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 00000045 - Disclosure - Schedule of other non-current assets (Details) link:presentationLink link:calculationLink link:definitionLink 00000046 - Disclosure - Other non-current assets (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 00000047 - Disclosure - Retirement benefit obligation (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 00000048 - Disclosure - Schedule of equity method investment and ownership percentage (Details) link:presentationLink link:calculationLink link:definitionLink 00000049 - Disclosure - Quotaholders’ and shareholders’ equity (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 00000050 - Disclosure - Schedule of Outstanding Stock Options (Details) link:presentationLink link:calculationLink link:definitionLink 00000051 - Disclosure - Schedule of share based compensation expenses (Details) link:presentationLink link:calculationLink link:definitionLink 00000052 - Disclosure - Share-based compensation (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 00000053 - Disclosure - Schedule of third party and related party expenses (Details) link:presentationLink link:calculationLink link:definitionLink 00000054 - Disclosure - Schedule of third party and general and administrative expenses (Details) link:presentationLink link:calculationLink link:definitionLink 00000055 - Disclosure - Schedule of accounts payable to related parties (Details) link:presentationLink link:calculationLink link:definitionLink 00000056 - Disclosure - Schedule of accrued expenses to related parties (Details) link:presentationLink link:calculationLink link:definitionLink 00000057 - Disclosure - Related parties (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 00000058 - Disclosure - Schedule of company obligations by contractual maturity (Details) link:presentationLink link:calculationLink link:definitionLink 00000059 - Disclosure - Commitments and contingencies (Details Narrative) link:presentationLink link:calculationLink link:definitionLink